Inositol hexanicotinate schizophrenia. I am recovering quite nicely on it.

• Inositol hexanicotinate schizophrenia 72. European Food Safety Authority (EFSA), European Food Safety Authority (EFSA) Search for more papers by Discover the transformative power of high-quality Flush Free Niacin powder! Our meticulously formulated Inositol Hexanicotinate is tailored for discerning individuals striving for a superior supplement experience. Journal of chromatography. Treatment of intermittent claudication with inositol nicotinate. In fact, the only thing I could find was "niacin Inositol Nicotinate is myo-inositol hexanicotinate. One popular form of dietary supplement is inositol hexanicotinate, usually sold as "flush-free" or "no-flush" niacin (although those terms are also used for regular sustained-release. It’s particularly noted for its significant benefits in brain function, insulin signal transduction, and fertility health. It contains not less than 98. Objective. C42 H30 N6 O12. A white or almost white powder. It should be pure niacin. , 2012). The use of the substance for nutritional purposes as a source of niacin in food supplements was assessed by the European Food Safety Authority (EFSA) in 2009. Large doses of B vitamins also help, specifically B6 & B12, but B8 Vitamin B3 is known as Niacin or nicotinic acid. My fasting T. I was looking for a bottle at my grocery store, and I couldn't find anything that only said inositol on the bottle. You can order it on Amazon or buy it from the vitamin store. Inositol hexanicotinate (IHN) self-micelle solid dispersion (SD) with glycyrrhizic acid (GA) and arabic gum (AG) was prepared by mechanical ball milling process to improve the solubility Mean blood levels (ng/ml) over 8 hours of NA after single dose of 500 mg of wax-matrix nicotinic acid (WMER) and 500 mg dose of inositol hexanicotinate (IHN). Definition. HTS Code Description No of Shipments; 2937 Hormones, prostaglandins, thromboxanes and leukotrienes, natural or reproduced by synthesis; derivatives and structural analogues thereof, including chain modified polypeptides, used primarily as hormones > Polypeptide hormones, protein hormones and glycoprotein Inositol hexanicotinate. Inclusion criteria: Male and female patients Aged between 20 &50 years. is supplier for Inositol hexanicotinate. Discover the transformative power of high-quality Flush Free Niacin powder! Our meticulously formulated Inositol Hexanicotinate is tailored for discerning individuals striving for a superior supplement experience. Inositol is a key metabolite in the phosphatidylinositol cycle, which is a second messenger system for serotonin-2 receptors that have been implicated in the pathophysiology of schizophrenia. Reference standards of Myo Inositol Hexanicotinate API, and its pharmacopeial, non pharmacopeial impurities, and stable isotopes are listed below. Other conditions. * Niacin (vitamin B3) is essential for a healthy metabolism and also helps support nervous system health. Holti G. Customer: Niacin also has an effect in premature aging, age related neurological disorders such as Alzheimer, arthritis, schizophrenia, ALS, muscular atrophy, Parkinson, Skin cancer (squamous cell), it helps with the circadian Hi everyone- I just got word that this was effective for schizophrenia and I tried it, it works GREAT! It is vitamin B8, it is also called Inositol. Inositol hexanicotinate is commonly referred to as no-flush niacin or flush-free niacin and is Inositol hexanicotinate . A number of other conditions which respond favorably to Inositol Hexanicotinate. All three forms are available without a prescription. Niacin plays a part in the production of stomach acid and bile. I recommend using Inositol hexanicotinate which is an extended-release version of niacin. 2013 Jan;7(1):14–23. "At a time of real progress in treatment of schizophrenia, Dr. has been a premier chemical supplier distributing high-quality chemicals to businesses in various industries for the whole world. Inositol hexanicotinate [JAN] Inositol Niacinate [USAN] inositol nicotinate [INN] [Wiki] inositoli nicotinas [Latin] [INN] Linodil . Inositol hexanicotinate has been found to improve blood flow by dilating blood vessels, which can be beneficial for conditions like Raynaud's phenomenon and severe intermittent claudication. (2) While the brain relies on glucose for energy, inositol plays a crucial role in regulating brain signaling pathways, which contributes to its reputation as a “nootropic” (cognitive enhancer). I learned about it by reading a post by a psychiatrist on the Psychiatric Times website extolling inositol as for anxiety, so I tried it. It also prevents the formation of lipids in the body, which helps to lower cholesterol and triglyceride levels. Neat. Every day I feel substantially better. In schizophrenia, the therapeutic range of the first three forms of vitamin B3 extend into the gram range (1000mg=1g). Arzneim-Frosch 1961;11:110-113. It provides 6 units of nicotinate per molecule with an inositol center. It suppresses appetite by raising insulin levels, giving a feeling of fullness. Elegantly packaged and sourced from the finest ingredients, it stands as the ideal enhancement to your daily wellness regimen. From manufacturing to packaging and delivery, we provide quality, Niacinamide and inositol hexanicotinate do not cause flushing, but their effects may differ slightly from basic niacin. Head, A. Some of the ingested inositol hexanicotinate is hydrolyzed in the body to slowly release free niacin and inositol. But I am using this a part of a regimen. It is available as a dietary supplement that has several health benefits; it is used to reduce elevated blood lipids, Inositol nicotinate is used for treating blood circulation problems, including pain when walking due to poor circulation in the legs (intermittent claudication); skin changes caused by pooling of the In this narrative review, we focused on the role of inositol in human brain physiology and pathology, with the aim of providing an update on both potential applications and current limits in its use in psychiatric disorders. Side Effects. 05 December, 2018 . Inositol hexanicotinate (inositol hexaniacinate) as a source of niacin (vitamin B3) added for nutritional purposes in food supplements. 100 g of nicotinic acid were suspended in 265 ml of distilled and dried pyridine without stirring. Int Record Med 1961;174:9-15. It is required by the body for the synthesis of the coenzymes NAD and NADP, which are required for many oxidation-reduction reactions. 11353443. Nicotinic acid (NA), long used for the treatment of dyslipidemia, has shown problems with undesirable side effects and safety issues. Product Format. Relevant identified uses: For R&D use only. Find a high-quality supplement. B, Analytical technologies in the biomedical and life sciences, 863(1), 172-176 (2008-01-22) A HPLC method with UV detection at 262nm was developed to analyze inositol hexanicotinate in rat plasma. Inositol hexanicotinate or IHN (six molecules of niacin bound to a single molecule of inositol) is the only form of niacin which causes neither redness nor flushes, thus providing all the benefits of higher-dose niacin (500 mg per vegicap) (Vitamin B3) molecules to form inositol hexaniacinate or inositol hexanicotinate. Abstract 1. Inositol nicotinate is also used for high cholesterol; high blood pressure; sleep problems ; migraines related to 'hardening of the arteries' (atherosclerosis); skin conditions, including It is also known as niacin (nicotinic acid) and has 2 other forms, niacinamide (nicotinamide) and inositol hexanicotinate, which have different effects from niacin. An experimentally controlled evaluation of the effect of inositol a water-soluble vitamin of the B complex (see vitamin), found in various animal and plant tissues, especially liver, yeast, bran, peanuts, lean meats, fish, and poultry. Andrew Saul had a patient that had been hospitalized for schizophrenia and Wax-matrix extended-release niacin vs inositol hexanicotinate: a comparison of wax-matrix, extended-release niacin to inositol hexanicotinate “no-flush” niacin in persons with mild to moderate dyslipidemia. It releases vitamin B3 into the body slowly to prevent the flushing effect but without the potential risks to the liver caused by niacinamide . Molecular Weight. It is functionally related to a nicotinic acid. Drug-Food Interactions: No interactions found/established. I've seen one review on amazon where somebody who takes it for schizophrenia said this brand didn't supress his symptoms compared to other brands of flush free niacin How does inositol hexaniconate feel ? Does it give a rush ? Nicotinic acid (also named Vitamin B3 or niacin) has 2 other forms, (nicotinamide/NAM, also named niacinamide) and inositol hexanicotinate, which have different effects from nicotinic acid. At low concentrations, the absorption of nicotinic An alternative is to use Inositol hexanicotinate, a form of Niacin which won't cause the flush. I think you can stimulate that crash by having a big meal with the Inositol Hexanicotinate. Doctor's Assistant chat. IHN was dissolved in dimethyl sulfoxide, diluted with acetonitrile, chromatographed on a Nova-Pak C 18 column with a mobile phase of water-methanol (40 + 60, v/v), and detected at 262 nm. Inositol hexanicotinate acts as a rich source of vitamin B3 (niacin), which plays an essential role in the utilization of carbohydrates, proteins, fats, oxidation-reduction reactions, cellular metabolism, and function of co-enzymes. " Inositol diminishes the mood swings, depression, Inositol Hexanicotinate Benefits; Health. Keywords:Mesotal manufacturer;Inositoli nicotinas supplier;Dilexpal factory;Inositol After single 50 or 100 mg/kg intravenous dose of IHN to Sprague-Dawley rats, the drug showed statistically significant dose-dependent alterations in systemic clearance, suggesting a non-linear saturable elimination of IhN. Version: 1. Inositol hexanicotinate, often known as flush-free or no-flush niacin, is a dietary supplement that has not been demonstrated to have any positive benefits on lipid markers [57, 58]. Myo inositol is actually used to treat sleep issues and anxiety in children and adults. Inositol hexanicotinate (IHN) has been studied for its benefits in treating dyslipidemia and hyperlipidemia. com for our official website Links: Benzonitrile, 4-[[3-[(4-cyclohexylphenoxy)methyl]phenyl]methoxy]- manufacturers | lithium tert-butyl(vinyl)amide suppliers. As 525 mg inositol hexanicotinate; Flush-free niacin; Flush reduced niacin; From 100 mg of inositol hexanicotinate; From 375 mg inositol hexaniacinate; From 640 mg of inositol hexanicotinate; From inositol hexanicotinate; Inositol hexaniacinate; Inositol hexaniacinate chromium polynicotinate; {inosi Show more Vitamin B3 (Inositol Hexanicotinate) (Group ID: Inositol hexanicotinate (IHN) is an ester of the anti-hyperlipidemic drug nicotinic acid (NA). W. Diabetes INOSITOL HEXANICOTINATE - This IHN supplement is a non flushing form of niacin, an essential B vitamin in high strength. Several trials of WMER demonstrated good efficacy in improving dyslipidemia; however, there are few scientific data on the use of IHN. Description Health benefits at a glance: First of all, what is niacin? It's a coenzyme that is called “B3” because it was the third B vi Found in various plants and animals, inositol comes in many forms, or isomers; however, the two most common are myo-inositol and D-chiro-inositol. C42H30N6O12 Not available. More evidence is needed to rate the effectiveness of inositol nicotinate for these uses. Niacin is an effective treatment for erectile dysfunction (ED) because it acts as a vasodilator that helps improve blood flow to the penis. Nicotinic acid given as inositol hexanicotinate in a dose of 10 mg per day would amount to a daily dose of 11 mg inositol hexanicotinate, with the release of 2. How inositol hexanicotinate works. Be particularly careful to clean folds, crevices, creases and groin. Hoffer mentions it’s effectiveness in schizophrenia and endothelial function but it lacks the cholesterol normalizing effect of regular niacin. Manufacturing Process. SAN PEDRO STREET GARDENA, Inositol hexanicotinate (inositol hexaniacinate) as a source for niacin (vitamin B3) The EFSA Journal (2009) 949, 7-20 Inositol hexanicotinate is to be used as a source of niacin in food supplements. . ] Source: Common Name While SR niacin reduces flushing, its effects on lipids have been variable, and it can cause hepatotoxicity. Mesonex . Figure 2. Nutritional status of vitamin A, E, C, B1, B2, B6, nicotinic acid, B12, folate, and beta-carotene in young women. It dissolves in dilute mineral acids. These other forms of niacin do not work in the same way as niacin. Or you can get a script Inositol hexanicotinate synonyms, Inositol hexanicotinate pronunciation, Inositol hexanicotinate translation, English dictionary definition of Inositol hexanicotinate. Product Code. The correlation Drug-Drug Interactions: Inositol Nicotinate may interact with anticoagulant drugs (clopidogrel, warfarin, heparin, dalteparin, enoxaparin, aspirin), lipid-lowering agents (atorvastatin, lovastatin, pravastatin, simvastatin), anti-diabetic (glimepiride, insulin, pioglitazone, glipizide). One Posters seem to have more side effects when the d chiro is added, many do fine with just myo inositol. n. Preliminary report. Please Do NOT confuse the Niacin (from 800 mg of inositol hexanicotinate) 640 mg° Inositol (from 800 mg of inositol hexanicotinate) 160 mg Other ingredients: gelatin, vegetable stearate. A HPLC method with UV detection at 262 nm was developed to analyze inositol hexanicotinate in rat plasma. Inositol is used for diabetic nerve pain, panic disorder, high cholesterol, insomnia, cancer, depression, schizophrenia, Alzheimer's disease, attention deficit-hyperactivity disorder (), autism, promoting hair growth, a skin disorder called psoriasis, and treating side effects of Wuhan PharmChem Co. It is sometimes used as a dietary supplement, with claims that it has various health benefits such as increasing blood flow and improving circulation, as well as lowering cholesterol levels and treating other conditions such as anxiety and depression. As an It is the most effective non-flushing niacin, more so than inositol hexanicotinate. Practically insoluble in water; practically insoluble in acetone, in ethanol (96%) and in ether. Welsh AL, Ede M. SPECTRUM CHEMICAL MFG. Plasma samples were extracted with an equal volume of acetonitrile, followed by dilution with mobile phase buffer (5 mM phosphate buffer, pH 6. Novel niacin extended-release (NER) In a study of first-episode schizophrenia inositol hexanicotinate (CAS No. Inositol Nicotinate, myo-Inositol Hexanicotinate. Anxiety disorders include post-traumatic Schizophrenia. 7. I have never found the “flush-free” form, also known as inositol hexaniacinate (hexanicotinate), to be effective. The good news is that, while not helpful, there is no A newer form of vitamin B-3 (), which does not cause flushing, is inositol hexaniacinate, sometimes called inositol hexanicotinate. The longevity component of niacin and niacin’s use in schizophrenia are other examples of the widespread utility of vitamin B3. In one study, there was a significant improvement in depression symptoms even when patients discontinued their antidepressants. Moreover, taking ER niacin inositol vs. Joined Jan 5, 2016 Messages 14,678 Location Inositol hexanicotinate; Click to expand Chronic, low-grade endotoxemia can also cause 2. Niacin can also increase homocysteine and blood glucose but research looking at this seems to indicate it's not a problem. Hoffer A: Healing Schizophrenia, Toronto, CCNM Press, 2004a, pp. Molecular Formula. Supports Cellular Health. 91 g nicotinic acid and 0. Inositol hexaniacinate delivers niacin in a natural slow-release way, allowing for all the cholesterol-modulating benefits of niacin with little The Panel concludes that a cause and effect relationship has been established between the consumption of the combination of artichoke leaf dry extract standardised in caffeoylquinic acids, monacolin K in red yeast rice, sugar-cane derived policosanols, OPC from French maritime pine bark, garlic dry extract standardised in allicin, d-α-tocopheryl hydrogen myo-Inositol Hexanicotinate. 497820-05-0) SDS. Myo Inositol Hexanicotinate is used for diabetic nerve pain, panic disorder, high cholesterol, insomnia, cancer, depression, schizophrenia. Vitamin B 6 (Pyridoxine) Vitamin B 6 (Pyridoxine) – Vitamin B 6 is needed to regulate homocysteine. Int Record Med 1961;174:9–15. Inositol hexanicotinate is sold as “no-flush” or “flush-free” niacin. It is also known as niacin (nicotinic acid) and has 2 other forms, niacinamide (nicotinamide) and inositol hexanicotinate, which have different effects from niacin. Another advantage of Key words: Niacin, Nicotinic Acid, HDL and Inositol Hexanicotinate. Common side effects of Inositol nicotinate. com Flush Free Niacin Powder - as Inositol Hexanicotinate, Vitamin B3 Supplement, Niacin 500mg Flush Free - Gluten Free, 500mg of per Serving, 100g (3. Not manufactured with wheat, gluten, soy, milk, egg, fish, No beneficial effect was demonstrated for inositol over placebo. Here Nutri Avenue summary all-sided info about Inositol Hexanicotinate. Avoid inositol hexanicotinate and nicotinic acid. Read on to find out more about how these different forms work and which one you should take for depression. Wax-matrix, extended-release niacin (WMER) and inositol hexanicotinate (IHN) have both been formulated to increase patient tolerability. 0/5 (0 Reviews) Directions. What happens When Inositol Hexanicotinate is Digested? Inositol Hexanicotinate has two metabolites (the chemicals that this substance breaks down Vitamin B3 (niacin, niacinamide, inositol hexanicotinate, NADH) is a strong methyl acceptor that has the potential to tame unregulated stress induced overproduction of neurotransmitters. Abram Hoffer and others developed in the 1950s, but which by the 1970s was proven to be fruitless. Inositol hexaniacinate Inositol hexanicotinate Of note, niacin has an additional important property that its vitamers do not have. INOSITOL HEXANICOTINATE: Locators: JAN Sources: Common Name English INOSITOL NICOTINATE [MART. The role of nicotinic acid and inositol hexaniacinate as anticholesterolemic and antilipemic agents. The primary difference between this and the other forms of Niacin is that Inositol Hexanicotinate releases much slower, reaching peak plasma levels as much as 6 hours after dosing. Niacin (Figure 2) is the generic term for both nicotinic acid and nicotinamide. In this scenario, a pioneering study in a small sample of patients with schizophrenia demonstrated that oral inositol significantly increased its CSF level by almost 70%, thus suggesting therapeutic applications . No-Flush Niacin contains a special form of niacin, inositol hexanicotinate, consisting of six molecules of niacin chemically linked to an inositol molecule. 14422 S. By promoting blood vessel dilation, inositol hexanicotinate can improve circulation and alleviate symptoms associated with these conditions. The amount of niacin that you need for schizophrenia tends to be very high. 68 g of HTS Codes used for imports of inositol hexanicotinate. This compound, a specialized form of niacin, has garnered attention for its potential health advantages. Inositol has been the most effective supplement I've tried. HDL < 40mg/dl. Please login or register to add to your favourites . Schizophrenia - A controlled double-blind crossover trial of 12 g daily of inositol for a month in twelve anergic schizophrenic patients, did not show any beneficial effects. Several trials of WMER demonstrated good efficacy in improving dyslipidemia; however, there are few Determination of inositol hexanicotinate in rat plasma by high performance liquid chromatography with UV detection. Inositol. Inositol hexanicotinate ( inositol hexaniacinate ) as a One of the most widely studied of these is inositol hexaniacinate (IHN). It cost only 15% of the Welsh AL, Eade M. I began at 800 mg Inositol Hexanicotinate two months before a complete workup. Studies have shown that when taking niacin ADHD risks are lowered. SDS. The influence of m-inositol hexanicotinate ester on the serum lipids and lipoproteins. Niacin should not be taken at high doses for long No-Flush Niacin contains inositol hexanicotinate which can allow true niacin activity without the characteristic niacin flush. Lower doses of vitamin B3 are required in ADD and ADHD. Several trials of WMER demonstrated good efficacy in improving dyslipidemia; however, there are few scientific data on the use of IHN. The primary difference between this and the other forms of Niacin is that Inositol Hexanicotinate releases much Inositol nicotinate has been used in conventional medical practice in Great Britain for improving symptoms of poor circulation for many years, although it is usually not the preferred treatment choice. Niacin exists in different forms including nicotinic acid, nicotinamide and other derivatives such as inositol nicotinate. Benefits & Mechanism of Action: Metabolic syndrome; insulin resistance As part of phospholipids in cellular membranes, phosphatidylinositol helps to mediate Inositol hexanicotinate, a form of niacin that is bound to inositol. This form of no flush niacin does NOT have the same impact as true niacin and does nothing to alter or reduce adverse lipid panels. com FREE SHIPPING on qualified orders Niacin is a wonder nutrient to be sure from lowering BP and cholesterol to being a very safe effective vasodilator to helping with schizophrenia, depression, Inositol hexanitrate | C6H6N6O18 | CID 23746 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities Niacin (inositol hexanicotinate*) 120 mg Inositol (inositol hexanicotinate) Niacin has been well researched for its ability to improve mental illnesses such as schizophrenia. It appears to be poorly absorbed, resulting in very little Niacin getting into our blood. One study compared the efficacy and tolerability of IHN with wax-matrix, extended-release niacin (WMER) and placebo. Inositol hexanicotinate (IHN) is a substitute for the normally used nicotinic acid (Vitamin B3), which is available with a prescription as a lipid-lowering drug and most commonly available over the counter as a diet supplement [184]. com or visit www. Oct 13, 2023; Thread Starter #6 OP. TRC, API Reference Standards & Research Materials, Additional Toxicology Reference Materials , Additional Solgar’s No-Flush Niacin (Inositol Hexanicotinate) complex has been carefully formulated using inositol-bound niacin which is a special complexed form of Niacin and does not come with this side effect. MeSH terms Humans Inositol / analogs & derivatives Niacin / analogs & derivatives Buy BulkSupplements. Inositol Hexanicotinate is a kind of niacin supplement for I take Niacin with flush. 1289248. If you were talking it for IR then intermittent fasting or diet changes are other routes to the same place. PMID: 13784278 No abstract available. Plasma samples were Inositol hexanicotinate Hexanicotinyl cis-1,2,3,5-trans-4,6-cyclohexane Not available. A well balanced diet usually supplies more than the daily requirement. The physicochemical Discover the transformative power of high-quality Flush Free Niacin powder! Our meticulously formulated Inositol Hexanicotinate is tailored for discerning individuals striving for a superior supplement experience. For many years, NAD + precursors, such as NA and NAM, were researched and utilised in treatment of pellagra, (AD) and schizophrenia, respectively Inositol Hexanicotinate. Dr. Inositol can be a useful supplement for patients dealing with a range of psychiatric conditions. The results showed that WMER demonstrated significant improvements in lipid profiles, while IHN was no better than placebo in lipid On the other hand, excessive dopamine activity has been linked to conditions like schizophrenia and addiction. Inositol hexanicotinate consists of six molecules of niacin chemically linked to an inositol molecule. Preliminary report Int Rec Med. Additional Orthomolecular Treatments. Just sent this over to my friend who suffers from Schizophrenia. Niacin is also used for treating and to help prevent schizophrenia. Those are the no-flush variants. Exclusion criteria: 1. 4. Flushing with ER niacin is minimized by taking it at bedtime. Some research suggests that it could be helpful for conditions like schizophrenia and depression. This formation allows it to deliver niacin to the bloodstream slowly and in a controlled fashion, avoiding both the unpleasantness of flushing and the danger of liver damage. Lack of association between schizophrenia and the phospholipase-A(2) genes cPLA2 and sPLA2. Inositol hexanicotinate for improved nicotinic acid therapy. 0) to eliminate any solvent effects. At Wuhan PharmChem, we are committed to excellence. No Flush Niacin contains inositol hexanicotinate, a special form of niacin. Practitioner 1986;230(1411):49 Go to schizophrenia r Inositol Hexanicotinate is a liver-safe no-flush niacin. (1,2) Spring Valley Niacin Inositol Hexanicotinate Metabolism Support Dietary Supplement Capsules are a dietary supplement formulated to promote metabolism support. 1961 Jan:174:9-15. It is associated with reduced flushing compared to other vasodilators by being broken down into Recommended nootropic dosage of niacin is 1000 mg 3-times per pay. In numerous trials it has been found to be virtually free of the side effects associated with conventional niacin therapy. 22 g inositol. CORP. Product Categories. OBJECTIVE: This study was designed to compare the efficacy and tolerability of WMER and IHN to each other and placebo to help clinicians make an Inositol hexanicotinate which works well for everything but you have to use more it costs a little more money and it doesn’t work as well and then sustained release niacin which is prescription, expensive and has the most side effects. I am recovering quite nicely on it. Authors A L WELSH, M EDE. Take one (1) capsule with food, or as Doctors who witnessed pellagrous dementia noticed many similarities to schizophrenia and theorized that schizophrenics might have a genetic disorder that required far greater levels of niacin. I see tons of comments and posts here about taking inositol and how it's benefited you all, especially compared to metformin. TRC-I666070. In schizophrenia, the ter of meso-inositol, inositol hexaniacinate (IHN), also called inositol hexanicotinate or inositol nicotinate. Expiry. 7-21. Nutr Reports Int 1983;28:899-911. I believe it might be due to quality control issues with this type Inositol is a key metabolite in the phosphatidylinositol cycle, which is a second messenger system for serotonin-2 receptors that have been implicated in the pathophysiology Evidence from animal and human studies has linked myo -inositol (MI) with the pathophysiology and/or treatment of psychiatric disorders such as schizophrenia and bipolar disorder. CAS No: 497820-05-0; Molecular Weight: 810. Niacin, niacinamide, inositol-bound niaicn (inositol hexanicotinate), and NADH are the four useful forms of vitamin B3 available for schizophrenia and ADD/ADHD. V. The maximum serum levels of nicotinic acid is reached approximately 6-10 hours after oral ingestion. Skin ContactAfter contact with skin, wash immediately with plenty of water. All B vitamins help the body convert food (carbohydrates) into fuel (glucose), which the body uses to produce energy. CAS Number. Gastrointestinal absorption of inositol hexanicotinate varies widely, with an average of 70% of an orally ingested dose absorbed from stomach and upper small intestines into the bloodstream as intact form. Gently and thoroughly wash the contaminated skin with running water and non-abrasive soap. This study was designed to compare the efficacy and tolerability of WMER and IHN I have never found the “flush-free” form, also known as inositol hexaniacinate (hexanicotinate), to be effective. Posted by u/Pointpleasant87 - No votes and no comments These results suggest that inositol has therapeutic effects in the spectrum of illness responsive to serotonin selective re-uptake inhibitors, including depression, panic and OCD, and is not beneficial in schizophrenia, Alzheimer's ADDH, autism or ECT-induced cognitive impairment. myo-Inositol hexanicotinate . It is hydrolyzed in the body to free niacin and inositol, which is a very slow process. In addition, inositol hexanicotinate (IHN) is also used for high cholesterol; high blood pressure; sleep problems (insomnia); migraines related to “hardening of the arteries” (atherosclerosis Pls send inquiry of inositol hexanicotinate CAS:6556-11-2 to info@nbinno. Molecular structure of nicotinic acid and nicotinamide both considered vitamers of niacin Inositol hexanicotinate. This compound has never been shown to release free niacin, raise circulating niacin levels, or improve plasma lipid levels. Inositol Hexanicotinate (IHN) That allows supplementing higher doses of nicotinic acid than people would tolerate, with longer time Introduction: Epidemiological data shows inverse relationship between high-density lipoprotein cholesterol (HDL-C) levels and cardiovascular diseases (CVD) signifying the role of high HDL-C in prevention of CVD. Drug-Disease Interactions: Inform your doctor Inositol hexanicotinate (inositol hexaniacinate) as a source for niacin (vitamin B3) The EFSA Journal (2009) 949, 7-20 Inositol hexanicotinate is to be used as a source of niacin in food supplements. SAFETY DATA SHEETS According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition. Uses advised against: none; Company myo-Inositol Hexanicotinate is an nicotinate conjugate of myo-inositol, an structural basis for a number of secondary messengers. Often described as no-flush Niacin with 25 articles of scientific literature published. Nicotinamide and inositol hexanicotinate (both sources of vitamin B3) have been useful in treating different types of addictions and schizophrenia since the 1950s (look for Dr Abram Hoffer' s videos (OMNS) Doctors report that mental health problems including depression, bipolar disorder, schizophrenia, ADHD, anti-social and learning disorders, and obsessive-compulsive disorders often have a common cause: insufficient nutrients in the brain. These The absorption of niacin from inositol hexanicotinate varies widely but on average is 30% lower than from nicotinic acid or nicotinamide, which are almost completely absorbed . My wife take inositol hexanicotinate a flush free Niacin. I have heard of some people getting appetite stimulation from too much insulin and a blood sugar crash afterwards, but I haven't had this. , LTD. The Authority considered such use to be safe provided that the levels of use Inositol nicotinate is a vasodilator and lipid-lowering agent. 6556-11-2. 2001 Apr 8. Key ingredients: Niacin as inositol hexanicotinate; Key Benefits: Niacin (vitamin B-3) plays a role in energy metabolism; Committed to providing quality reference materials for food and beverage testing, buy Inositol hexanicotinate online at LGC Standards. Mechanism of action, how it works Myo Hexopal (Hexanicotinate inositol) has shown promise in uncontrolled studies and its use in patients with Inositol hexanicotinate for improved nicotinic acid therapy. Directions. Cholesterol had declined Not dangerous at all: Inositol hexanicotinate was widely presumed to help lower cholesterol in a manner similar to Niacin (which works quite well) without the annoying flush, but recent research suggests it is not particularly effective. Dong Liang et al. Yes. However, for some people, anxiety becomes excessive, difficult to control and negatively impacts day-to-day living. Picamilon Inositol Hexanicotinate is a kind of niacin supplement for healthy lipid levels. There are two other forms of niacin: niacinamide and inositol hexanicotinate. Emotional and physical stress often leads to feelings of anxiety. It had a dramatic effect on my symptoms with no side effects, not a thing, it is harmless, only a vitamin. They don’t work. 23 mmol) inositol hexanicotinate yields 0. From improving blood circulation to supporting metabolic functions, this substance plays a role The mainstay of the orthomolecular approach to schizophrenia is or () in high amounts. DRE-C14328220. Often discussed in the context of cardiovascular health and overall well-being, it offers a range of benefits that are worth exploring. 4 mg inositol upon hydrolysis. This study assessed the hydrolysis rate of IHN in human and rat plasma, and pharmacokinetics of the How to say inositol hexanicotinate in English? Pronunciation of inositol hexanicotinate with 1 audio pronunciation and more for inositol hexanicotinate. Meds/Supplements Long time reader, first time poster. SAN PEDRO STREET GARDENA, CA 90248 CALL (310) 516-8000 SPECTRUM CHEMICAL MFG. Creation View All Manufacturers & Suppliers of INOSITOL, HEXANICOTINATE, myo- API with Drug Master Files (DMF), CEP/COS, Japanese DMFs, Written Confirmation (WC) details listed on PharmaCompass. This study assessed the hydrolysis rate of IHN in . * The suggested adult dosage is one capsule daily, preferably with a meal. European Food Safety Authority (EFSA), European Food Safety Authority (EFSA) Search for more papers by this author. It can also be made in a laboratory. DeMarco has written about an approach which Dr. Not for medicinal, household or other use. Its novel properties allow for true niacin activity without the characteristic niacin flush. com - Inositol Excipient - Magnesium Sulfate Excipient, Unspecified - Maltose Excipient - Mannitol - METHYL BETA D GALACTOPYRANOSIDE - MPEG2000-DSPE One of the most widely studied of these is inositol hexaniacinate (IHN). I started having a panic attack (one of the "benefits" of long covid) because I thought I would overdose on it. Inositol May Be Helpful for Depression. and Fischer, F. 5 oz) (Pack of 1) on Amazon. 0% of C 42 H 30 N 6 O 12, calculated with reference to the dried substance. 732; Molecular Formula: C 42 H 30 N 6 O 12; Names and Identifiers Properties Safety and Handling. But, you could just try something else entirely like NAC or Berberine. Related topics Topic Replies Inositol hexanicotinate isn’t just another form of inositol; instead, it’s more closely associated with vitamin B3, known as niacin. It is found in many plants and animals. I am currently using Inositol Hexanicotinate (a very tolerable form of Niacin, doesn't flush you or give you liver issues), up to 9 grams a day. Anxiety is a normal reaction to stress in moderation. As a substitute for traditional nicotinic acid, IHN can significantly reduce the triglyceride levels without acute side effects, probably due to the sustained release of the nicotinic acid by enzymatic hydrolysis in vivo Takeaway: 2 grams daily of myo-inositol may aid in maintaining a healthy body composition when used along with diet and lifestyle changes. Things get interesting, however, when inositol hexanicotinate starts to be digested. Lot Number. This is the non-flushing form of vitamine B3 which slowly gets hydrolised into B3 and inositol over a long period of time. B It is used in food supplements as a source of niacin , where hydrolysis of 1 g (1. Niacin causes flushing, whereas products labeled no flush niacin typically contain inositol hexanicotinate. Inositol is part of the structural basis for a variety of Inositol nicotinate is a compound formed from the combination of inositol and nicotinic acid (also known as niacin). Inositol hexanicotinate has also been prescribed as a form of niacin (“flush free”); however, there is evidence that the nicotinic acid is poorly released from the Inositol hexanicotinate (IHN) self-micelle solid dispersion (SD) with glycyrrhizic acid (GA) and arabic gum (AG) was prepared by mechanical ball milling process to improve the solubility, stability of amorphous state, and bioavailability of IHN, which enhanced the treatment of IHN on hyperlipidemia and nonalcoholic fatty liver disease (NAFLD). Inositol hexanicotinate (no-flush niacin) works, too, but not quite as well. We would like to show you a description here but the site won’t allow us. Ehrenstorfer. there's been a lot of interest in niacin supplementation for schizophrenia because the manifestations of myo-inositol hexanicotinate (CHEBI:31699) is a inositol hexanicotinate (CHEBI:33064) IUPAC Name cyclohexane-1,2,3,4,5,6-hexayl hexanicotinate Synonyms Sources hexanicotinoyl inositol ChemIDplus inositol niacinate Health Benefits of Inositol Hexanicotinate. Top Inositol Hexanicotinate (IHN) In 2009, the European Food Safety Authority (EFSA) Scientific Panel on Food Additives and Nutrient Sources Added to Food concluded that nicotinate from IHN is a bioavailable source of niacin (EFSA 2009). In Inositol hexanicotinate the Niacin molecyle is binded with a Inositol molecyle and it make the release slower without affecting the liver. Inositol levels are lower than normal in people with depression. J Clin Lipidol [Internet]. First Aid Measures Eye ContactNo known effect on eye contact, rinse with water for a few minutes. High homocysteine levels are linked to Inositol hexanicotinate is a nicotinic acid derivative2 and, as nicotinic acid can be released from it, is used as a source of niacin. nicotinate d'inositol [French] [INN] nicotinato de inositol [Spanish] [INN] Palohex [Trade name] инозитола никотинат [Russian] Hexaniacinate d’Inositol, Hexanicotinate d’Inositol, Hexanicotinate de Meso-Inositol, Hexanicotinyl cis-1,2,3-5-trans-4,6-cyclohexane, Hexanicotinoyl Inositol, Inositol Hexaniacinate, Inositol Hexanicotinate, Inositol Niacinate, Meso-Inositol Hexanicotinate, Myo-inositol hexa-3-pyridine-carboxyalte, Niacinate d’Inositol, Niacine Sans Rougissement, Product name: Inositol nicotinate ; CBnumber: CB4411387; CAS: 6556-11-2; EINECS Number: 229-485-9; Synonyms: INOSITOL,Inositol nicotinate; Relevant identified uses of the substance or mixture and uses advised against. It improves circulation by releasing histamine, which causes the blood vessels to dilate and breaks up a protein needed for the clotting of blood. Identification. Inositol hexanicitonate is prescribed as Hexopal in Europe for Raynaud’s syndrome at 4 grams a day, so apparently it is somewhat safe and benefits vasodilation and peripheral circulation. It appears not to be bioavailable (hence the lack of flushing) and should not be used. Product Type Native/Parent. Norepinephrine levels, which are closely related to dopamine, (also called nicotinamide), and inositol hexanicotinate. 3. nbinno. A white crystalline acid, C6H5NO2, of the vitamin B complex that is found in meat, fish, legumes, and whole-grain foods and is used to treat and prevent In addition to its physical health benefits, niacin may also support mental health. 0% and not more than 101. Inositol hexanicotinate, or inositol niacinate, is a form of niacin, or vitamin B3 2. And does not cause the typical niacin flush. These B vitamins, often referred to as B-complex vitamins, also help the body use fats and protein. While the term “inositol” can sometimes be used interchangeably with myo-inositol in supplements and health discussions, it’s important to recognize that myo Antoneta only, What are the benefits of taking Niacin Inositol Hexanicotinate 500mg (Flush Free) and Milk Thistle 1000mg. 810. This article explains that it simply breaks down after absorption to nicotinic acid and an insignificant amount of inositol. 16/03/2025. NON-GMO, GLUTEN FREE, SOY FREE, VEGAN - Supersmart offers you an Food supplements, niacin, nicotinic acid, vitamin B3, inositol hexanicotinate, inositol hexaniacinate, CAS Registry Number 6556-11-2 Question number EFSA-Q-2005-213 Inositol is a vitamin-like substance. niacin inositol hexanicotinate . Characteristics. Often described as ‘no flush Niacin’ with 25 articles of scientific literature published. Nevertheless, monotherapy with niacinamide has completely resolved schizophrenia. 0. IHN was incorporated into a solid 21st Century Niacin Inositol Hexanicotinate 500 mg Capsule is a gluten-free vitamin supplement that helps boost energy levels and enhances circulation. Hoffer’s standard prescription was three thousand Niacin vs Inositol Hexanicotinate . ChEBI: Inositol hexanicotinate is an inositol nicotinate. Inositol hexanicotinate and the internal standard (mebendazole) were A precise and selective liquid chromatographic procedure for determining inositol hexanicotinate (IHN) in formulated preparations was developed and validated. Reported as early as 1955, niacin has been documented to lessen the abnormal lipid metabolism that promotes atherosclerosis. Molecular structure of nicotinic acid and nicotinamide both considered vitamers of niacin Inositol hexanicotinate (IHN) is a niacin ester consisting of six molecules of niacin and one molecule of inositol (Fig. Niacin. Within 5 days of starting inositol, my anxiety began to fade significantly. API Family. Mesotal . B Niacin (Vitamin B-3)(from 640 mg of Inositol Hexanicotinate) 500 mg 2500% Inositol(from 640 mg of Inositol Hexanicotinate) 135 mg† Other Ingredients: Rice Flour, Cellulose (capsule), Cellulose Powder, Stearic Acid (vegetable source), Guar Gum, Silica and Magnesium Stearate (vegetable source). ) While this form of niacin does not cause the flushing associated with the nicotinic acid form, it is not clear whether it is pharmacologically equivalent in its positive effect. myo-lnositol Hexa-3-pyridinecarboxylate . Nicotinic acid is the form most commonly associated with the “niacin flush,” Myo-inositol, on the other hand, is one specific form of inositol and is the most abundant in the human body. El-Enein AMA, Hafez YS, Salem H, Abdel M. 1 A) (MacKay et al. When six niacin molecules are attached to a large molecule of inositol, inositol hexaniacinate is the result. 15 It is me-tabolized in the body into its component parts, O CO OCO OCO HO OCO Esterase CO O N N N NIACIN N COOH N FIGURE 1. Wuhan PharmChem Co. also offers 2-Isopropylimidazole. meso-Inositol Hexanicotinate . A study published in the journal Medical Science Monitor found that niacin supplementation improved symptoms of depression in patients with bipolar disorder. Extensive research has found IHN to be effective in the treatment of hyperlipidemia, Raynaud’s disease and intermittent claudication. Vitamin B3 can help in varying degrees with the following conditions/symptoms: fatigue, heart disease and high cholesterol (niacin or inositol hexanicotinate), ADD (mind-running), PTSD, schizophrenia, osteoarthritis, Alzheimer’s disease, erectile dysfunction, and eye conditions. The effects of IHN on NAFLD have rarely been investigated due, in part, to its low availability [184]. David PS Member. The compound consists of six molecules of nicotinic acid and one mol-ecule of inositol (See Figure 1). I believe it might be due to quality control issues with this type of preparation, or due to the inositol component of it. inositol hexanicotinate (IHN) have both been formulated to increase patient tolerability. Inositol hexanicotinate (IHN) is an ester of the anti-hyperlipidemic drug nicotinic acid (NA). It also helps the digestion of fats, carbohydrates and protein because niacin is needed in the coenzymes that speed up these reactions. In early double-blind trials, 3 grams of niacin daily resulted in a doubling of the recovery rate, a 50% reduction in hospitalization rates, and a dramatic reduction in suicide rates. Niacin, known as nicotinic acid has been available for years as a vitamin supplement, although its high dose usage to treat dyslipidemia is restricted by an Nicotinamide and inositol hexanicotinate (both sources of vitamin B3) have been useful in treating different types of addictions and schizophrenia since the 1950s (look for Dr Abram Hoffer' s videos There are two forms – nicotinamide (also called niacinamide) and inositol hexanicotinate. According to Dr. 2001 Feb. Hopefully this can convince him to at the last try dosing Niacin for a month and see if he has improvements. Two niacin-like compounds, nicotinamide riboside and nicotinamide mononucleotide (NMN; also referred to as β-NMN), are also available as dietary supplements, but are not marketed or labeled as sources Inositol hexanicotinate Section 4. It is free from added sugar, salt, yeast, preservatives, artificial flavors, or colors. Written by Owen Bond . Niacin & Anxiety. Then googled more and saw they are a bit different. Nutritionally-oriented physicians assert that the cure for these problems is to give the body the extra nutrients it needs, Inositol hexanicotinate is a clever artificial molecule. Learn more. Each form has its own characteristics and potential benefits. Hoffer A: Atypical Niacin, niacinamide, inositol-bound niaicn (inositol hexanicotinate), and NADH are the four useful forms of vitamin B3 available for schizophrenia and ADD/ADHD. NM7535400 6556-11-2 I1003 Not available. Food additives, flavours and adulterants, Dr. Vitamin D3 100,000+ IU, K2 MK4, Daily Essential Minerals by Hardy Nutritionals (chelated vitamin complex), John Ellis water and Inositol hexanicotinate is a six-molecule chemical compound comprising of 6 nicotinic acid molecules and inositol molecule present in the center. Hoffer: “ Niacin and niacinamide are equally effective for schizophrenia, but higher doses of niacin can be tolerated without nausea. Are they both helpful with long covid or only pure niacin is? I took 1 gram of Hexanicotinate yesterday and then googled Niacin and it said that 25mg is the recommended dose. Inositol supplementation shows promise for reducing depression symptoms. NIACIN FLUSH FREE - Our supplement is the only form of niacin which causes neither redness nor flushes, thus providing all the benefits of higher-dose niacin. Inositol has shown promise in alleviating symptoms of depression and anxiety. gdsn avmmkw ftfgw lsyo rtgq ydks pdcqewh xkm vocjso dydi