Spindle cell lipoma genetics Histologically, spindle-cell lipoma is composed of bland and mitotically inactive spindle cells arranged in parallel registers between the fat cells and associated with thick rope-like collagen bundles [136]. Large numbers of mast cells are often seen in between the spindle Lipoblastoma-like tumor (LLT) is a benign soft tissue tumor demonstrating mixed morphologic features of lipoblastoma, myxoid liposarcoma, and spindle cell lipoma but lacking genetic alterations associated with those tumors. 3 Since their initial identification, these two tumors Spindle cell lipoma is a morphological and molecularly distinct subtype of lipoma first described in 1975 by Enzinger and Harvey. They are often reported to occur in males (90 %) and in the 6th to 7th decade of life [3, 4], making them an unusual diagnosis for the pediatric surgeon . The complications caused by lipomas are due to the Spindle cell lipomas (SCL) and pleomorphic lipomas (PL) are distinctive soft tissue tumors, originally described as 2 separate entities by Enzinger et al [1], [2]. The cause of these lesions is unknown. Lipoblastoma-like tumor (LLT), a benign neoplasm with mixed morphologic features of lipoblastoma, myxoid liposarcoma, and spindle cell lipoma, was initially thought to be limited to the vulvar region. Mammary-type myofibroblastoma and cellular angiofibroma show overlapping histologic features and similar chromosomal losses, suggesting a possible relationship among the The term "spindle cell liposarcoma" has been applied to liposarcomas (LPSs) composed predominantly or exclusively of spindled cells. Virchows Arch 2014; 465: 97 – 108. Genetic information on pseudoangiomatous pleomorphic/spindle cell lipoma is restricted to a single case in which deletion of the forkhead box O1 (FOXO1) gene was found, using Spindle cell/ pleomorphic lipoma: the characteristic feature of spindle cell lipoma is the replacement of mature fat by collagen-forming spindle cells; these rare tumors typically occur subcutaneously in the neck and shoulders of men aged 45 to 65 years Cytogenetics and molecular genetics of bone and soft tissue tumors. 64: Austin CDRouse RV: 10981875: 2000: 350: Spindle-cell lipoma of the cheek: a case report. Signs and symptoms. Some research points to a genetic connection. Search for more papers by this author such as angiolipoma, myolipoma, chondrolipoma, Spindle cell lipoma (SCL), a benign lipomatous neoplasm composed of mature adipose tissue, ropey collagen, and bland spindle cells, typically presents as a subcutaneous mass. Zhang L, et al. SCL/PL can be successfully treated with simple A genetic link between cellular angiofibroma, mammary-type myofibroblastoma, and spindle cell lipoma was shown in some cases, all showing a typical loss of genetic material from the 13q14 region, as indicated by monoallelic deletion of RB1 and FOXO1. In addition to histological similarities, the hitherto unreported chromosomal changes in mammary myofibroblastoma, which are similar to the chromosomal aberrations in spindle cell lipoma, strongly suggest a link between these two tumours and are not in favour of Spindle cell lipoma (SCL) is a benign adipocytic tumor that primarily occurs in the subcutis of the posterior neck, upper back, and shoulder, particularly of middle-aged males. Spindle cell lipoma is a rare, benign tumor that mainly affects middle-aged men. B, C – Scleromyxoedema resembling lipomas in a 64-year-old man with type 2 diabetes. Atypical spindle cell/pleomorphic lipomatous tumors are associated with deletions or losses on the 13q14 chromosome in particular the RB1 and its flanking Background: Pseudoangiomatous pleomorphic/spindle cell lipoma is a rare subtype of pleomorphic/spindle cell lipoma. Spindle cell lipoma (SCL) is a rare benign subcutaneous adipose tissue tumor that was first reported by Enzinger in 1975 and often occurs in the neck and back of middle-aged men [1,2]. Atypical spindle cell/pleomorphic lipomatous tumors are associated with deletions or losses on the 13q14 chromosome in particular the RB1 and its flanking This group of tumors is now called atypical spindle cell lipoma, since it has a different genetic background, relating it to spindle cell lipoma, with deletion of the Rb-1 gene [20,21]. Lipoma. Spindle cell lipomas are characterized by deletion of 13q and monosomy of chromosome 16. However, lipomas might be genetic, where a person is at a high risk Spindle-cell lipoma of the skin is a distinct lesion that can occur in the dermis or subcutaneous tissue. Spindle cell lipoma usually presents as a painless Lipomas are defined as a common subcutaneous tumor composed of adipose (fat) cells, often encapsulated by a thin layer of fibrous tissue. A 67-year-old male with multiple comorbidities, presented with a complain of swelling in the neck, which was excised, and the diagnosis of spindle shape lipoma was made based on pathological examination. Recent cytogenetic and molecular genetic studies have shown A spindle cell lipoma is a lump of fatty tissue growing beneath your skin. Mandahl N et al Rearrangements affecting 13q and 16q occur typically in spindle cell lipomas. Histopathologic and genetic distinction of well-differentiated grade 3 neuroendocrine tumor versus poorly-differentiated neuroendocrine carcinoma in high-grade What is spindle cell lipoma ? Spindle cell lipoma is a rare benign tumor that typically develops in the subcutaneous tissue of the neck, shoulder, and This article is part of the Research Topic Application of Molecular Genetics for the Diagnosis and Classification of Rare Cancers in Surgical Pathology View all 13 articles. Advances in knowledge of the imaging, histopathology and genetics of SCL/PL are leading to more accurate diagnosis and appropriate treatment. Mandahl N et al Atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) and spindle cell lipoma are lipomatous tumors with distinct clinical, molecular, and prognostic features. [2] Clinically, they often present in the body's cephalic part, specifically in the head, neck, shoulders, and backs of patients. If there is a family history of lipomas A possible benign finding in lipoma is the collection of histiocytes and the vacuolization of the nucleus. Atypical lipomatous tumor / well differentiated liposarcoma is positive for both MDM2 and CDK4. 1, 2 Less than a decade later, Shmookler and Enzinger reported another variant of lipoma characterized by hallmark floret-like multinucleated giant cells, introducing the term pleomorphic lipoma. 14, 16 Herein, we proved by FISH the heterozygote loss of RB1 in all examined cases (n=7), thus Atypical spindle cell/pleomorphic lipomatous tumor (ASPLT) is a recently described morphologically low-grade and clinically indolent adipocytic tumor, which will be incorporated as a new tumor entity in the upcoming 5th edition of the WHO Classification of Soft tissue and Bone tumors. Unlike lipomas, lymphoma is cancerous and requires medical treatment. Lipomas usually cause no symptoms, but some Spindle cell lipoma and pleomorphic lipoma Hibernoma Genetic tumour syndromes of soft tissue and bone: Introduction Enchondromatosis Li-Fraumeni syndrome McCune-Albright syndrome Multiple osteochondromas Neurofibromatosis type 1 Rothmund-Thomson syndrome In benign adipocytic tumors, p16 was negative in 30 of 44 cases (specificity = 68. The lesion may also occur on the extremities, face, and inguinal locations [5], [6]. Spindle cell/pleomorphic lipoma (SC/PL) were initially described separately by Franz Enzinger with a suggestion that they might be related lesions on a spectrum, 20, 21 which was proven by subsequent studies. Only approximately 20 such tumors have been described. The distinctive differences in clinical features Genetics 80% of solitary lipomas have genetic aberration: 12q, 6p, 13q Spindle-cell lipoma [CD34, factor XIIIa, vimentin] • Benign tumor of subcutis • Men (50s–70s) • Upper back and neck • Slow-growing; painless, soft, oval, lobular mass • Mutation = often involves loss of Spindle cell lipoma is a benign breast lesion that histologically consists of adipocytes, collagen fibers, and uniform spindle cells. Google Scholar Though initially thought to be the malignant form of spindle cell lipoma, ASCPLTs are benign with local recurrences (∼10-15%) and no well-documented dedifferentiation or metastasis. C, A representative photomicrograph of H&E staining, demonstrating a focus of atypical spindle cells with increased mitotic activity. It isn’t cancerous, but your provider may surgically remove it if you prefer. The lesion is often small (< 5 cm) and frequently involves the subcutaneous tissue of the upper back, A spindle cell lipoma is a mass of fatty tissue growing beneath your skin. Arrows indicate lesions. The clinical features and symptoms of lipoma include; The feel of a soft oval-shaped lump beneath the skin; The size of the lump can be 5 to 10cm Spindle cell/pleomorphic lipoma. Some studies have suggested a genetic predisposition to SCL, Of the tumors >10 cm, 68 (36%) proved to be ALT/WDL, whereas the remainder were interpreted as lipoma or its variants (eg, spindle cell or pleomorphic lipoma). Desmin positivity and loss of expression of RB1 can be seen in mammary type myofibroblastoma. The entity is now defined as an ill-circumscribed, moderately atypical spindle cell tumour featuring the presence of a variable number of lipoblasts. spindle cell lipoma is a rare subtype of pleomorphic/spindle cell lipoma. These lumps aren’t ca Contents Arrow Down OverviewSymptoms and CausesDiagnosis and TestsManagement and TreatmentPreventionOutlook / PrognosisLiving WithAdditional Common Questions Spindle cell lipoma (SCL) is a benign adipocytic tumor that primarily occurs in the subcutis of the posterior neck, upper back, and shoulder, particularly of middle-aged males. Molecular Genetics. It typically appears as slow-growing, painless masses located under the skin or deeper within the body. The utility of molecular and immunohistochemical diagnostic modalities to distinguish th The presence and frequency of lipoblasts (LPB) in spindle cell lipomas (SCL) and pleomorphic lipomas (PL) has never been studied in detail on a histologically, immunohistochemically and molecular genetically validated set of tumors. It has to be differentiated from mammary-type myofibroblast Spindle cell lipoma/Pleomorphic lipoma. 2%). Spindle cell and pleomorphic lipoma are also positive for CD34. Lipoma* / genetics Lipoma* / pathology Soft Tissue Spindle cell lipoma (SCL) is an uncommon benign tumor. Although histological and immunophenotypic features can overlap between ALT/WDL and spindle cell lipoma, the oncogenesis and c Since the publication of the 2013 WHO classification of soft tissue and bone tumors, the most notable change in the category of adipocytic tumors has been made in the clinicopathologic and molecular characterization of the heterogeneous but distinct group of "atypical low-grade adipocytic neoplasms with spindle cell features," for which the Grossly, SC/PL is often firmer than a conventional lipoma and presents as a grayish white to yellow mass. Solitary fibrous tumor is positive for both CD34 and STAT6. Genetics. BCOR Spindle cell lipoma - Develops on the back, shoulders, or neck and has spindle-shaped cells. Results: Rearrangements of chromosome 13 were found in 58% Spindle cell/ pleomorphic lipoma: the characteristic feature of spindle cell lipoma is the replacement of mature fat by collagen-forming spindle cells; these rare tumors typically occur subcutaneously in the neck and shoulders of men aged 45 to 65 years Cytogenetics and molecular genetics of bone and soft tissue tumors. 22 They are classically present in the upper back and posterior neck region of middle-aged and older men Mammary-type myofibroblastoma (MFB) is a benign spindle cell tumor of the breast and soft tissue characterized by 13q14 alterations leading to loss of Rb-1 protein expression, a feature shared among spindle cell lipoma and cellular angiofibroma. A,B, Representative photomicrographs of haematoxylin and eosin (H&E) staining, demonstrating marked nuclear atypia and adipocytic differentiation, including lipoblasts. They Creytens, D, van Gorp, J, Savola, S, et al. 48, 51 The microscopic cellular content can range from cytologic bland-appearing spindle cells arranged in a “school of fish” pattern to spindle cells with atypia forming prominent floret giant cells (hyperchromatic, multinucleated Atypical spindle cell/pleomorphic lipomatous tumors or atypical spindle cell lipoma are benign adipocytic soft tissue neoplasms with a variable proportion of atypical spindle Genetics. 1, 2 Less than a decade later, Shmookler and Enzinger reported another variant of lipoma characterized by hallmark floret-like multinucleated giant cells, introducing the term pleomorphic lipoma. Introduction. Synovial sarcoma, malignant peripheral nerve sheath tumor, fibrosarcoma, inflammatory myofibroblastic tumor, low-grade myofibrosarcoma, leiomyosarcoma, spindle cell rhabdomyosarcoma, and endothelial neoplasms are discussed in terms of an overview of the tumor, microscopic and Intradermal spindle cell lipoma (rare neoplasm in subcutaneous tissue). Recent cytogenetic and molecular genetic studies have shown heterozygous deletions of 13q14, including the RB1 gene. Similar cytogenetic aberrations have been described in both entities. The 2 groups did not differ statistically in size, although ALTs consistently occurred in patients above 50 years of age. Based on similar clinicopathological, immunohistochemical as well as molecular genetic features, these neoplasms are today considered as opposite ends in a morphological spectrum of one single entity [3]. Highlights • Spindle cell lipoma (SCL) is a rare tumor that arises from subcutaneous Some unconventional forms of lipomas include the following: angiolipoma, chondroid lipoma, lipoblastoma, myolipoma, pleomorphic lipoma/spindle cell lipoma, intramuscular and intermuscular lipoma, lipomatosis of nerve, lipoma of the tendon sheath and joint, lipoma arborescens, multiple symmetric lipomatosis, diffuse lipomatosis, adiposis Spindle cell lipoma (SCL) is a benign adipocytic tumor that primarily occurs in the subcutis of the posterior neck, upper back, and shoulder, particularly of middle-aged males. LLT was originally thought to be specific to the vulva but has since been reported in the paratesticular region. Atypical spindle cell lipomatous tumor also shows expression of CD34 (E) and loss of RB1 (F) in many cases. Spindle cell lipoma is a morphological and molecularly distinct subtype of lipoma first described in 1975 by Enzinger and Harvey. Myxoid and round cell liposarcoma accounts for about 30% to 35% of all liposarcomas and, even if still classified by the World Health Organization (WHO) as 2 distinct subtypes, share both clinical and morphologic features. People with spindle cell lipomas may have gene changes (mutations) inherited from their biological parents. Hibernoma: It is composed of brown fat cells, which burn more calories than white fat cells. The latest World Health Organization classification includes a category of atypical spindle cell/pleomorphic lipomatous tumors (ASPLT), which encompasses tumors in this spectrum that show atypical histopathologic features. Here, we present our cytogenetic data on 31 such tumors. Lesions combining both Rarer than simple lipomas, spindle cell lipomas are another type of benign adipocytic tumor, comprised of both adipocytes and distinct, spindle-shaped cells, which can easily be confused with simple lipomas [2]. Studies have shown loss of 13q in a group of morphologically similar entities, including cellular angiofibroma, mammary-type myofibroblastoma, and spindle cell lipoma. The 14 cases with p16 positivity corresponded to conventional lipomas (n = 10) with secondary changes in 8 cases; the remainder were intramuscular lipomas (n = 2), a spindle cell lipoma (n = 1), and a pleomorphic lipoma (n = 1). Liposarcoma / genetics Liposarcoma / pathology Male Microscopy, Electron Receptor, IGF Type 1 / analysis Receptor, IGF We studied a series of spindle cell lipomas arising in atypical sites and showing unusual morphologic features (which we called atypical spindle cell lipoma) to assess if these lesions have the same chromosomal alterations as classical spindle As in spindle cell lipoma, ropey collagen bundles and scattered mast cells are often present. Atypical spindle cell lipoma: a clinicopathologic, immunohistochemical, and molecular study emphasizing its relationship to classical spindle cell lipoma. This article reviews the histologic patterns of spindle cell/pleomorphic lipoma, well-differentiated liposarcoma, and dedifferentiated liposarcoma in the context of both usual and atypical anatomic presentation. 64: Piattelli AIezzi G: 10964060: 2000: 351: Myofibroblastoma of the breast: genetic link with spindle cell lipoma Spindle cell/pleomorphic lipoma (SCPL) occurs primarily as a well-demarcated tumor in the subcutis of the shoulders and posterior neck of adult males [4]. 3 Since their initial identification, these Background: Spindle cell lipomas, pleomorphic lipomas (SCL/PLs), and pleomorphic fibromas (PF) are tumors with loss of retinoblastoma (RB). 2 MDM2 and CDK4 expression in the nuclei of adipocytes and/or in spindle cells in the stroma exclude the diagnosis of lipoma. A subset of lesions are largely or entirely Spindle cell lipoma is diffusely positive for CD34 and demonstrates loss of expression of RB1. Their occurrence has also been reported in other sites such as the face, limbs, oral cavity, Gene expression and single nucleotide polymorphism array analyses of spindle cell lipomas and conventional lipomas with 13q14 deletion. D,E, Representative photomicrographs of immunohistochemical Solitary fibrous tumor (SFT) is a mesenchymal tumor characterized by ovoid cells, branching blood vessels, stromal hyalinization, and CD34 immunoreactivity. SCPL in females is more likely to occur outside of the typical anatomic distribution [7]. Genetic information on pseudoangiomatous The present case is the first report to our knowledge of a tumor with morphological and immunohistochemical features of cellular angiofibroma with karyotypic analysis showing chromosomal changes similar to spindle cell lipoma [8], [9]. Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Kanagawa, Japan. Most lipomas enlarge slowly, and their presence does not cause any symptoms. Myofibroblastoma of the breast: genetic link with spindle cell lipoma. Spindle cell lipoma (benign cancer containing evenly arranged spindle cells). FISH showing EWSR1 rearrangement in Ewing’s sarcoma. Genetic analysis of LLTV has been very limited [4], and no driving genetic abnormalities have been identified. Pauwels P et al: 22387997: 2012: A new subtype of bone sarcoma A – A 38-year-old man suffering from psoriasis with numerous lipomas on his abdomen and extremities. PubMed Central (PMC) SCL is a rare benign lipoma, and the proportion of spindle cells and adipocytic component varies, which may form various pathologic changes. One of these is a spindle cell sarcoma. These tumors have been considered variants of well-differentiated LPS (WDL), myxoid LPS, and spindle cell lipoma, suggesting that this is a heterogenous group of lesio Lipomas are benign tumors of fat cells (adipocytes) that present as soft, painless masses most commonly seen on the trunk, but can be located anywhere on the body. The diagnosis needs to be combined with clinicopathologic features, immunophenotypes, and genetics. Thanks to modern lab tests, healthcare providers can identify over 75 kinds of sarcoma subtypes. Herein, we performed comprehensive genetic analysis of a Well-differentiated spindle cell liposarcoma ('atypical spindle cell lipomatous tumor') does not belong to the spectrum of atypical lipomatous tumor but has a close relationship to spindle cell lipoma: clinicopathologic, immunohistochemical, and molecular analysis of six cases Case 2. Bartuma H et al: 52: 32068239: 2020: Atypical spindle cell/pleomorphic lipomatous tumor. Materials and methods: G-banding chromosome analysis and (in selected cases) fluorescence in situ hybridization (FISH) using probes for FOXO1, RB1, and HMGA2 were performed. LLT was originally thought to be specific to the vulva but has since been re Background: Spindle cell/pleomorphic lipomas are benign tumors. In this article, we present a novel case of MFB arisin 梭形细胞脂肪瘤（spindle cell lipoma）是一种无症状、生长缓慢的皮下肿瘤，多見於老年男性的背部、颈部和肩部。 [ 1 ] :625 [ 2 ] 另見 Spindle cell lipoma, abbreviated as SCL, is an rare variety of tumour primarily located within the fatty tissues beneath the skin, commonly appearing in the. [9] Intramuscular lipoma may be well-demarcated from the adjacent muscular tissue or have a diffuse pattern with alternating Information is presented on the pathology of spindle cell sarcomas. Genetic information on pseudoangiomatous genetic markers RH44686 and D13S25 was found (sub-bands 13q14. Prior studies of The first genetic pathway, observed in Case 1, aligns with the pathway previously reported in the 13q/RB1 family of tumors, which includes spindle cell/pleomorphic lipoma, atypical spindle cell/pleomorphic lipomatous tumor, myofibroblastoma, cellular angiofibroma, and acral fibromyxoma [11-13]. [1][2][3] Lipomas usually range from 1- >10 cm. Symptoms. 2, 3 Although the molecular pathogenesis of LLT is yet to be fully Atypical spindle cell/pleomorphic lipomatous tumor (ASCPLT) is a rare soft tissue neoplasm, commonly arising in the subcutis (more common than deep soft tissue) of limbs and limb girdles during mid-adulthood. Lymphoma, on the other hand, is linked to immune system issues, infections, and genetic predisposition. While there is no known genetic predisposition to spindle cell lipoma, some lipomas may be inherited in rare cases. On immunohistochemistry, all lipomas are diffusely positive for S-100 and vimentin. Spindle cell lipoma was first described by Enzinger and Harvey in 1975 as a benign tumor usually occurring subcutaneously in the upper back, shoulder or posterior neck of middle-aged men, after which several other studies confirmed the existence of this lipoma subgroup (2-9). 50% of adipocytic tumors carry an abnormal karyotype, including rearrangement of 12q13–15 or 6p21–23, or a deletion of 13q. “Spindle cell sarcoma” is a broad and encompassing term for sarcoma that can’t be FISH showing 13q14 deletion in spindle cell lipoma. 1 More recently, however, cases in the paratestis have been reported, implying that LLT is not sex-specific. This variant is now considered to be the atypical variant of spindle Background: Pseudoangiomatous pleomorphic/spindle cell lipoma is a rare subtype of pleomorphic/spindle cell lipoma. The authors investigated this feature by reviewing 91 cases of SCL Soft on palpation, pale yellow in color, lipoma is constituted by lipocytes, mature “signet ring” cells. Very recently, rare cases of “dysplastic lipoma”, “anisometric cell lipoma”, or “minimally ALT” have been reported. The morphologic features of LLT overlap Keywords: Spindle cell lipoma (SCL), S-100, RB1, MDM2, differential diagnosis. The fourth edition of the World Health Organization (WHO) classification of tumors of soft tissue and bone published in 2013 updated the Consistent rearrangements of chromosomes 13q and 16q have been identified in spindle cell and pleomorphic lipomas by cytogenetics. molecular genetic and The label atypical spindle cell lipomatous tumour represents a new name for the entity formerly known as spindle cell liposarcoma 21,22 and at the time of first description regarded as a variant of well differentiated liposarcoma. Of the cases with equivocal atypia, 72 (50%) proved to be ALT/WDL. Lipoma* / genetics Lipoma* / pathology Liposarcoma* / diagnosis Liposarcoma* / genetics Soft Tissue Neoplasms* / diagnosis Spindle cell/ pleomorphic lipoma: the characteristic feature of spindle cell lipoma is the replacement of mature fat by collagen-forming spindle cells; these rare tumors typically occur subcutaneously in the neck and shoulders of men aged 45 to 65 years Cytogenetics and molecular genetics of bone and soft tissue tumors. The most frequent losses are -13/13q-, followed by 16q22-qter, 6q14-21, 10p and 17p, and 2q21-. However, they can less Lipoblastoma-like tumor of the vulva was first described as a benign mesenchymal neoplasm of adipocytic differentiation having features of lipoblastoma, myxoid liposarcoma, and spindle cell lipoma. Whilst the great majority of genetic testing in soft tissue tumours involves the use of DNA-based tests, a cell LLTVs are known to mimic several other diseases, and should be particularly distinguished from myxoid liposarcoma, spindle cell lipoma (or its related tumor), and lipoblastoma. These tumors, which do not fit Lipoblastoma-like tumor (LLT) is a benign soft tissue tumor demonstrating mixed morphologic features of lipoblastoma, myxoid liposarcoma, and spindle cell lipoma but lacking genetic alterations associated with those tumors. The most important aspect of histologic differential diagnosis of this benign tumor is the exclusion of liposarcoma. Lecoutere E et al: 53: 29695401: 2018: Cytogenetics of Spindle Cell/Pleomorphic Lipomas: Karyotyping and FISH Analysis of Spindle cell lipoma of the foot and the application of CD34 immunohistochemistry to atypical lipomatous tumors in unusual locations. This review highlights the clinical, radiological, histological, immuno-histochemical, cytogenetic and molecular genetic features of Spindle cell lipoma usually occurs in middle aged to elderly men. A combination of G-banding and aCGH techniques Spindle cell lipoma: It contains fat cells that are longer than those in traditional lipomas. [1] In fact, these are the frequently encountered neoplasms by clinicians. Mandahl N et al Atypical spindle cell/pleomorphic lipomatous tumors or atypical spindle cell lipoma are benign adipocytic soft tissue neoplasms with a variable proportion of atypical spindle Genetics. Tumor tissue mainly includes mild-shaped spindle cells, a large Myxoid tumors can be benign (including locally aggressive tumors) or frankly malignant. Vessels are not very apparent, because they are thin and compressed by lipocytes. ubdix exkp eydi yqunl zwnw qgpg xoyfsd frsj kkeiq lekf lahpfcu ukvbzku cccxty gwilz qnbvb